Mechanism of induction of RNA tumor viruses by halogenated pyrimidines.

摘要: Frome these studies on JLS V-9 cells, a number of conclusions can be drawn about the mechanism MuLV induction by halogenated pyrimidines. The compounds induce virus from otherwise healthy cells as long deoxycytidine is present along with inducing agent. must during S phase cell cycle and incorporated into DNA in order to (Teich et al. 1973). Only one strand need substituted BrdU or IdU virus, because one-hour period incorporation leads induction. From results it possible construct model for how pyrimidines are able viruses uninfected cells. Because critical compound restricted segment cell, there would appear genetic information which, when IdU, transcriptional derepression. Presumably either controlling element integrated provirus separate gene which controls expression provirus. Whichever true, strongly imply that search specific repressors segments mammalian likely successful RNA tumor may offer system such repression systems identified investigated.