Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer.

摘要: Abstract Mammary carcinoma kinase 10 (MCK-10) and colon 2 (CCK-2) constitute a subclass of receptor tyrosine kinases characterized by discoidin I motif in the extracellular domain large cytoplasmic juxtamembrane (JM) region. While ectodomain structure suggests common role cell aggregation, JM domains MCK-10 CCK-2 are structurally most divergent display features that suggest an involvement signal generation definition. occurs at least three isoforms, which contain alternatively spliced consensus sequences for internalization SH3 interaction. The presence 37 amino acid insert affects autophosphorylation changes glycosylation. Proteolytic cleavage within generates membrane-anchored releases soluble fragment including homology domain. expression was found connective epithelial tissues, respectively, cancers origin results mutually exclusive stroma tumor cells, indicating possible this class RTKs invasion.