Comparative genomics provides evidence for close evolutionary relationships between the urotensin II and somatostatin gene families
作者： Hervé Tostivint , Lucille Joly , Isabelle Lihrmann , Caroline Parmentier , Alexis Lebon
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摘要: Although urotensin II (UII) and somatostatin 1 (SS1) exhibit some structural similarities, their precursors do not show any appreciable sequence identity and, thus, it is widely accepted that the UII SS1 genes derive from a common ancestral gene. The recent characterization of novel isoforms these two peptides, namely II-related peptide (URP) 2 (SS2)/cortistatin (CST), provides new opportunity to revisit phylogenetic relationships using comparative genomics approach. In present study, by radiation hybrid mapping in silico analysis, we have determined chromosomal localization encoding UII- somatostatin-related peptides several vertebrate species, including human, chicken, zebrafish. most species investigated, URP are closely linked SS2/CST genes, respectively. We also found UII-SS2/CST locus URP/SS1 paralogous. Taken together, data indicate on one hand, other arose through segmental duplication were already physically each other. Our results suggest themselves tandem single It thus appears belong same superfamily.
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