Cerebral dysfunction with evidence of cerebral HIV infection amongst asymptomatic HIV seropositive subjects.

摘要: Twelve asymptomatic HIV seropositive subjects ages 21 to 40 years were examined for serologic evidence of cerebral infection, structural abnormalities, and neuropsychologic dysfunction using standard methods. Eleven the 12 had antibody in cerebrospinal fluid (CSF). Nine oligoclonal immunoglobulins CSF, whom five some which there no corresponding serum ('unique' immunoglobulins). Intracerebral synthesis specific antibodies was demonstrated four subjects. Significant deficits memory frontal lobe function found Subjects who unique CSF all significant neuropsychological abnormalities. No abnormalities CT scanning any subject tested. These results support other that is neurotropic capable directly inducing brain damage even immunologically normal Tests are frequently abnormal patients with early identify as a similar group immunological or biochemical tests might indicate infection.