Labeled chemotactic peptides to image focal sites of infection or inflammation

作者: Robert Harold Rubin , Daniel John Kroon , Douglas James Riexinger , Anthony Joseph Fuccello , Alan Jay Fischman

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摘要: This invention relates to a method of detecting site infection or inflammation, and for treating such in an individual by administering the diagnostically therapeutically effective amount detectably labeled, therapeutic, therapeutically-conjugated, chemotactic peptide that accumulates substantially at infected inflamed site, said having general structure X—Y—Leu—Phe—[Z]n—W wherein X is amino protecting group, Y acid residue, Z spacer sequence, n 0 1, W labeling attachment substituent.

参考文章(85)
Janet A. Johnson, Martin P. Sandler, Paul F. Parks, Leslie Homra, Jeremy J. Kaye, Michael J. Christie, Detection of Occult Infection Following Total Joint Arthroplasty Using Sequential Technetium-99m HDP Bone Scintigraphy and Indium- 111 WBC Imaging The Journal of Nuclear Medicine. ,vol. 29, pp. 1347- 1353 ,(1988)
Steven M. Larson, Radiolabeled Monoclonal Anti-Tumor Antibodies in Diagnosis and Therapy The Journal of Nuclear Medicine. ,vol. 26, pp. 538- 545 ,(1985)
Robert H. Rubin, H. William Strauss, Method for the diagnosis and treatment of inflammation ,(1987)
John W. F. Goers, Chyi Lee, Richard C. Siegel, Thomas J. McKearn, John D. Rodwell, Vernon L. Alvarez, Antibody-metal ion complexes ,(1985)
Don L. Kreutzer, Henry J. Showell, Elmer L. Becker, Peter A. Ward, Joseph T. O'Flaherty, Inhibition of in Vivo and in Vitro Neutrophil Responses to Chemotactic Factors by a Competitive Antagonist Journal of Immunology. ,vol. 120, pp. 1326- 1332 ,(1978)
I. TORRINI, G. PAGANI ZECCHINI, M. PAGLIALUNGA PARADISI, G. LUCENTE, E. GAVUZZO, F. MAZZA, G. POCHETTI, S. SPISANF, A.L. GIULIANI, Synthesis and properties of chemotactic peptide analogs International Journal of Peptide and Protein Research. ,vol. 38, pp. 495- 504 ,(2009) , 10.1111/J.1399-3011.1991.TB01532.X
Ville Valtonen, Gunnar Myllylä, Kristian Liewendahl, Martti T. Syrjälä, Diagnostic significance of indium-111 granulocyte scintigraphy in febrile patients The Journal of Nuclear Medicine. ,vol. 28, pp. 155- 160 ,(1987)
B Dolmatch, J Niedel, Formyl peptide chemotactic receptor. Evidence for an active proteolytic fragment. Journal of Biological Chemistry. ,vol. 258, pp. 7570- 7577 ,(1983) , 10.1016/S0021-9258(18)32216-6
William N. Rom, Commentary: research on the mechanisms of the occupational lung diseases. Archives of Environmental Health. ,vol. 39, pp. 186- 189 ,(1984) , 10.1080/00039896.1984.9939522
Claudio Toniolo, Gian Mario Bonora, Henry Showell, Richard J. Freer, Elmer L. Becker, Structural requirements for formyl homooligopeptide chemoattractants. Biochemistry. ,vol. 23, pp. 698- 704 ,(1984) , 10.1021/BI00299A018