Taming cancer by inducing immunity via dendritic cells

作者: A. Karolina Palucka , Hideki Ueno , Joseph W. Fay , Jacques Banchereau

DOI: 10.1111/J.1600-065X.2007.00575.X

关键词:

摘要: Immunotherapy seeks to mobilize a patient's immune system for therapeutic benefit. It can be passive, i.e. transfer of effector cells (T cells) or proteins (antibodies), active, vaccination. In cancer, passive immunotherapy lead some objective clinical responses, thus demonstrating that the reject tumors. However, is not expected yield long-lived memory T might control tumor outgrowth. Active with dendritic cell (DC)-based vaccines has potential induce both tumor-specific and cells. Early trials testing vaccination ex vivo-generated DCs pulsed antigens provide proof-of-principle immunity elicited. Yet, there need improve their efficacy. The next generation DC generate large numbers high-avidity CD8(+) overcome regulatory Therapeutic protocols will combine improved vivo therapies offset suppressive environment established by

参考文章(266)
Arlene H Sharpe, E John Wherry, Rafi Ahmed, Gordon J Freeman, None, The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection Nature Immunology. ,vol. 8, pp. 239- 245 ,(2007) , 10.1038/NI1443
Carl H. June, Principles of adoptive T cell cancer therapy Journal of Clinical Investigation. ,vol. 117, pp. 1204- 1212 ,(2007) , 10.1172/JCI31446
David Jarrossay, Giorgio Napolitani, Marco Colonna, Federica Sallusto, Antonio Lanzavecchia, Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. European Journal of Immunology. ,vol. 31, pp. 3388- 3393 ,(2001) , 10.1002/1521-4141(200111)31:11<3388::AID-IMMU3388>3.0.CO;2-Q
S. González, V. Groh, T. Spies, Immunobiology of Human NKG2D and Its Ligands Current Topics in Microbiology and Immunology. ,vol. 298, pp. 121- 138 ,(2006) , 10.1007/3-540-27743-9_6
Ellen Puré, James P Allison, Robert D Schreiber, Breaking down the barriers to cancer immunotherapy. Nature Immunology. ,vol. 6, pp. 1207- 1210 ,(2005) , 10.1038/NI1205-1207
Frank O. Nestle, Selma Alijagic, Michel Gilliet, Yuansheng Sun, Stephan Grabbe, Reinhard Dummer, Günter Burg, Dirk Schadendorf, Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nature Medicine. ,vol. 4, pp. 328- 332 ,(1998) , 10.1038/NM0398-328
Ignacio Melero, Sandra Hervas-Stubbs, Martin Glennie, Drew M. Pardoll, Lieping Chen, Immunostimulatory monoclonal antibodies for cancer therapy Nature Reviews Cancer. ,vol. 7, pp. 95- 106 ,(2007) , 10.1038/NRC2051
Jens Dannull, Johannes Vieweg, Donna Niedzwiecki, Eli Gilboa, Axel Heiser, Scott Pruitt, Donna Yancey, John Madden, Doris Coleman, Zhen Su, Immunological and Clinical Responses in Metastatic Renal Cancer Patients Vaccinated with Tumor RNA-transfected Dendritic Cells Cancer Research. ,vol. 63, pp. 2127- 2133 ,(2003)
Eli Gilboa, The Makings of a Tumor Rejection Antigen Immunity. ,vol. 11, pp. 263- 270 ,(1999) , 10.1016/S1074-7613(00)80101-6