Frequent PIK3CA activating mutations in nipple adenomas.

摘要: Aims Nipple adenoma (NA) is a rare benign epithelial tumour occurring in the nipple. Histologically, it exhibits variable and often mixed adenosis-like usual ductal hyperplasia-like growth patterns. Morphologically, similar to other proliferative breast lesions parenchyma, which have been shown harbour activating mutations PIK3CA, AKT1 or, less frequently, RAS more than 50% of cases. In this study, we aimed analyse mutation status AKT1, BRAF NAs correlated with histological features. Methods results Mutation analysis was performed 24 by Sanger sequencing. Our results showed that PIK3CA were identified eight 15 (53%) predominantly pattern four nine (44%) pattern. One H1047R also had KRAS Q61H mutation. Two tumours an V600E mutations. Overall, half (12 24, 50%) our series 58% (14 24) or mutations. Conclusions Our data indicate that, are very common NAs, may occur concurrently addition, as has not previous studies, BRAF-mutated appear distinct pathogenesis.