Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions

作者: Anders Bach , Søren W. Pedersen , Liam A. Dorr , Gary Vallon , Isabelle Ripoche

DOI: 10.1038/SREP12157

关键词:

摘要: … Here, we investigate the proposed mechanism of action of ZL006 … the applied in vitro conditions, ZL006 and IC87201 do not … for further medicinal chemistry efforts of ZL006, IC87201 …

参考文章(43)
SK Florio, C Loh, SM Huang, AE Iwamaye, KF Kitto, KW Fowler, JA Treiberg, JS Hayflick, JM Walker, CA Fairbanks, Y Lai, Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents. British Journal of Pharmacology. ,vol. 158, pp. 494- 506 ,(2009) , 10.1111/J.1476-5381.2009.00300.X
John C. Owicki, Fluorescence Polarization and Anisotropy in High Throughput Screening: Perspectives and Primer Journal of Biomolecular Screening. ,vol. 5, pp. 297- 306 ,(2000) , 10.1177/108705710000500501
Jonas N. N. Eildal, Greta Hultqvist, Thomas Balle, Nicolai Stuhr-Hansen, Shahrokh Padrah, Stefano Gianni, Kristian Strømgaard, Per Jemth, Probing the Role of Backbone Hydrogen Bonds in Protein–Peptide Interactions by Amide-to-Ester Mutations Journal of the American Chemical Society. ,vol. 135, pp. 12998- 13007 ,(2013) , 10.1021/JA402875H
Michelle Aarts, Yitao Liu, Lidong Liu, Shintaro Besshoh, Mark Arundine, James W Gurd, Yu-Tian Wang, Michael W Salter, Michael Tymianski, Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions Science. ,vol. 298, pp. 846- 850 ,(2002) , 10.1126/SCIENCE.1072873
Søren W. Pedersen, Stine B. Pedersen, Louise Anker, Greta Hultqvist, Anders S. Kristensen, Per Jemth, Kristian Strømgaard, Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations Nature Communications. ,vol. 5, pp. 3215- 3215 ,(2014) , 10.1038/NCOMMS4215
Hidehito Tochio, Yu-Keung Mok, Qiang Zhang, Ho-Man Kan, David S. Bredt, Mingjie Zhang, Formation of nNOS/PSD-95 PDZ dimer requires a preformed β-finger structure from the nNOS PDZ domain Journal of Molecular Biology. ,vol. 303, pp. 359- 370 ,(2000) , 10.1006/JMBI.2000.4148
L.-L. Li, V. Ginet, X. Liu, O. Vergun, M. Tuittila, M. Mathieu, C. Bonny, J. Puyal, A. C. Truttmann, M. J. Courtney, The nNOS-p38MAPK Pathway Is Mediated by NOS1AP during Neuronal Death The Journal of Neuroscience. ,vol. 33, pp. 8185- 8201 ,(2013) , 10.1523/JNEUROSCI.4578-12.2013
Myron D. Ginsberg, Neuroprotection for ischemic stroke: past, present and future. Neuropharmacology. ,vol. 55, pp. 363- 389 ,(2008) , 10.1016/J.NEUROPHARM.2007.12.007
Bryan H Chang, Taranjit S Gujral, Ethan S Karp, Raghida BuKhalid, Viara P Grantcharova, Gavin MacBeath, A Systematic Family-wide Investigation Reveals that ∼30% of Mammalian PDZ Domains Engage in PDZ-PDZ Interactions Chemistry & Biology. ,vol. 18, pp. 1143- 1152 ,(2011) , 10.1016/J.CHEMBIOL.2011.06.013
M. A. Stiffler, J. R. Chen, V. P. Grantcharova, Y. Lei, D. Fuchs, J. E. Allen, L. A. Zaslavskaia, G. MacBeath, PDZ domain binding selectivity is optimized across the mouse proteome. Science. ,vol. 317, pp. 364- 369 ,(2007) , 10.1126/SCIENCE.1144592