Interaction between Metabotropic and Ionotropic Glutamate Receptors Regulates Neuronal Network Activity

摘要: Experimental and computational techniques have been used to investigate the group I metabotropic glutamate receptor (mGluR)-mediated increase in frequency of spinal cord network activity underlying locomotion lamprey. Group mGluR activation potentiated amplitude NMDA-induced currents identified motoneurons crossed caudally projecting interneurons. mGluRs also calcium responses. This effect was blocked by a mGluR-specific antagonist, but not blockers protein kinase A, C, or G. The tested on oscillations known occur during fictive locomotion. Activation these receptors increased duration plateau phase decreased hyperpolarizing phase. These effects were antagonist. To determine its role modulation locomotor burst frequency, potentiation NMDA simulated using techniques. Simulating interaction between reproduced hyperpolarized phases oscillations, rhythm. Our results thus show postsynaptic lamprey neurons, which can account for regulation output mGluRs.