Iridoids and sesquiterpenoids of Valeriana stenoptera and their effects on NGF-induced neurite outgrowth in PC12 cells.
作者： Fa-Wu Dong , Zhi-Kun Wu , Liu Yang , Chen-Ting Zi , Dan Yang
DOI: 10.1016/J.PHYTOCHEM.2015.08.015
关键词:
摘要: Twenty-one compounds (nine iridoids and twelve sesquiterpenoids), including ten previously unknown (five five sesquiterpenoids) were isolated from whole dried material of Valeriana stenoptera. Structures established on the basis extensive spectroscopic analysis relative stereochemistry 13-hydroxypatchoulol A was further confirmed by X-ray crystallographic data. All isolates evaluated for their effects nerve growth factor (NGF)-mediated neurite outgrowth in pheochromocytoma (PC12) cells seven showed potent promoting effects.
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