Tolerability and Healthcare Utilization in Maintenance Hemodialysis Patients Undergoing Treatment for Tuberculosis-Related Conditions.

摘要: Background: The incidence of tuberculosis (TB) in end-stage renal disease is significantly higher than that the general population. Among those with kidney dysfunction, anti-TB treatment associated increased side effects, but effect on healthcare utilization unknown. Methods/Aim: To assess patient-reported symptoms, adverse effects and describe changes patterns during for TB, we conducted a case series (n = 12) patients receiving maintenance hemodialysis (HD) from Mayo Clinic Dialysis Services concurrent drug therapy TB January 2002 through May 2014. Healthcare (hospitalizations emergency department (ED) visits independent hospital admission) was compared before treatment. Results: Patients were treated latent 7) or active 5) TB. majority isoniazid 5, 71%), while active-disease received 4-drug regimen. Adverse reported 83% patients. Compared to measurements prior initiation, serum albumin dialysis weights similar at 3 months. Commonly toxicities described. More half (58%) hospitalized least once. No ED admissions occurred period therapy, group (hospitalization rate per person-month: pre 0 vs. post 1). Conclusions: HD patients, frequently symptoms utilization. this subset, may be greatest increase use. Careful monitoring early complication detection help optimize medication adherence minimize hospitalizations.