Diverse modes of action of progesterone and its metabolites

摘要: Abstract Progesterone and its metabolites have a variety of diverse effects in the brain, uterus, smooth muscle, sperm oocyte. The include changes electrophysiological excitability, induction anesthesia, regulation gonadotropin secretion, estrogen receptors, modulation uterine contractility acrosome reaction oocyte maturation. latency vary from several seconds to hours. Thus, it is not surprising that multiple mechanisms action are involved. classical mechanism steroid hormone intracellular receptor binding has been supplemented by possibility acting as transcription factor after protein DNA. Other influence steroids on membrane fluidity through other cell signalling systems, receptors GABA A receptors. Of particular interest for same types action. For example effect progesterone gondadotropin release largely exerted via well whereas 3α,5α-tetrahydroprogesterone-induced LH occurs system. inhibition regulated while 3α,5α-tetrahydroprogesterone differences pattern dynamics anterior pituitary uterus animal also considerable interest.