Degradation of mitomycin C in acidic solution
作者： J.H. Beijnen , W.J.M. Underberg
DOI: 10.1016/0378-5173(85)90022-5
关键词:
摘要: Abstract The degradation of mitomycin C in acidic medium has been investigated utilizing a stability indicating high-performance liquid Chromatographic assay and ultraviolet spectrophotometry. Rate constants for the decomposition at 20°C are determined pH profile was constructed. ratio between two mitosene products as function is quantified. mechanism solution evaluated.
sci-hub.se 参考文章(27)
D. D. Perrin, Dissociation Constants of Organic Bases in Aqueous Solution ,(1965)
J.H. Beijnen, J. Den Hartigh, W.J.M. Underberg, Qualitative aspects of the degradation of mitomycins in alkaline solution Journal of Pharmaceutical and Biomedical Analysis. ,vol. 3, pp. 71- 79 ,(1985) , 10.1016/0731-7085(85)80008-X
M. BEAN, H. KOHN, Studies on the reaction of mitomycin C with potassium ethyl monothiocarbonate under reductive conditions Journal of Organic Chemistry. ,vol. 48, pp. 5033- 5041 ,(1983) , 10.1002/CHIN.198427181
A. Aszalos, Analysis of Antitumor Antibiotics by High Pressure Liquid Chromatography (HPLC) Journal of Liquid Chromatography & Related Technologies. ,vol. 7, pp. 69- 125 ,(1984) , 10.1080/01483918408073937
U. HORNEMANN, K. IGUCHI, P. J. KELLER, H. M. VU, J. F. KOZLOWSKI, H. KOHN, Reactions of mitomycin C with potassium ethyl xanthate in neutral aqueous solution Journal of Organic Chemistry. ,vol. 48, pp. 5026- 5033 ,(1983) , 10.1002/CHIN.198427180
Leung Cheng, William A. Remers, Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene. Journal of Medicinal Chemistry. ,vol. 20, pp. 767- 770 ,(1977) , 10.1021/JM00216A006
Paul A. Andrews, Su-Shu Pan, Nicholas R. Bachur, Liquid chromatographic and mass spectral analysis of mitosane and mitosene derivatives of mitomycin c Journal of Chromatography A. ,vol. 262, pp. 231- 247 ,(1983) , 10.1016/S0021-9673(01)88102-4
Wesley G. Taylor, William A. Remers, Structure and stereochemistry of some 1,2-disubstituted mitosenes from solvolysis of mitomycin C and Mitomycin A Journal of Medicinal Chemistry. ,vol. 18, pp. 307- 311 ,(1975) , 10.1021/JM00237A020
W.J.M. Underberg, H. Lingeman, Aspects of the chemical stability of mitomycin and porfiromycin in acidic solution Journal of Pharmaceutical Sciences. ,vol. 72, pp. 549- 553 ,(1983) , 10.1002/JPS.2600720518
Shukuo Kinoshita, Keizo Uzu, Kinichi Nakano, Mikio Shimizu, Toshinaka Takahashi, Masanao Matsui, Mitomycin derivatives. 1. Preparation of mitosane and mitosene compounds and their biological activities. Journal of Medicinal Chemistry. ,vol. 14, pp. 103- 109 ,(1971) , 10.1021/JM00284A005