Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma
作者： Cheng-Fang Tsai , Tsung-Hua Hsieh , Jau-Nan Lee , Chia-Yi Hsu , Yu-Chih Wang
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摘要: Recent evidence indicating that phthalates promote cancer development, including cell proliferation, migration, and invasion, has raised public health concerns. Here, we show bis(2-ethylhexyl) phthalate promotes the epithelial-mesenchymal transition of hepatocellular carcinoma cells. In addition, increased proportion stem (CSC)-like cells stemness maintenance in vitro as well tumor growth metastasis vivo. The various activities curcumin, anticancer, anti-inflammation, antioxidation, immunomodulation, have been investigated extensively. Curcumin suppressed phthalate-induced transition, decreased CSC-like lines vitro, inhibited We also reveal curcumin through inhibition aryl hydrocarbon receptor/ERK/SK1/S1P3 signaling pathway. Our results suggest may be a potential antidote for progression.
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