Aptamer conjugates for targeting of therapeutic and/or diagnostic nanocarriers

作者: Bobby N. Trawick , Todd A. Osiek , Jr. James R. Wheatley

DOI:

关键词:

摘要: The present invention provides targeted delivery compositions and their methods of use in treating diagnosing a disease state subject. In one aspect, the can include compositon, comprising: (a) nanocarrier including therapeutic or diagnostic agent combination thereof; (b) conjugate having formula: A- [(EG) (P)]n-T; wherein, A is an attachment component for attaching to nanocarrier; (P)]n linking group, wherein subscript n integer from 1 about 40; each EG independently selected group consisting triethylene glycol, tetraethylene pentaethylene hexaethylene heptaethylene octaethylene glycol; P phosphate thiophosphate; and, T targeting agent.

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