Bicyclic derivatives useful as inhibitors of dpp-1

作者: Renee L. Desjarlais , Carsten Schubert , Shyamali Ghosh , Dennis J. Hlasta , Edward C. Lawson

DOI:

关键词:

摘要: The present invention is directed to novel bicyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders conditions modulated by DPP-1.

参考文章(14)
Hans Bundgaard, Design of prodrugs Elsevier , Sole distributors for the USA and Canada, Elsevier Science Pub. Co.. ,(1985)
Christopher Andrew Luckhurst, Mark Furber, Peter Alan Cage, Hitesh Jayantilal Sanganee, Linda Anne Stein, Peptidyl nitriles and use thereof as dipeptidyl peptidase i inhibitors ,(2008)
Herbert A. Lieberman, Leon Lachman, Pharmaceutical dosage forms : tablets Marcel Dekker. ,(1980)
Päivi H. Kiviranta, Jukka Leppänen, Valtteri M. Rinne, Tiina Suuronen, Olga Kyrylenko, Sergiy Kyrylenko, Erkki Kuusisto, Anu J. Tervo, Tomi Järvinen, Antero Salminen, Antti Poso, Erik A.A. Wallén, N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors Bioorganic & Medicinal Chemistry Letters. ,vol. 17, pp. 2448- 2451 ,(2007) , 10.1016/J.BMCL.2007.02.023
Christopher E. Neipp, Michael R. Palovich, Cathepsin C inhibitors ,(2012)
Gregory I. Elliott, James R. Fuchs, Brian S. J. Blagg, Hayato Ishikawa, Houchao Tao, Z.-Q. Yuan, Dale L. Boger, Intramolecular diels-alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles. Journal of the American Chemical Society. ,vol. 128, pp. 10589- 10595 ,(2006) , 10.1021/JA0612549
Nathalie Méthot, Daniel Guay, Joel Rubin, Diane Ethier, Karen Ortega, Simon Wong, Denis Normandin, Christian Beaulieu, T. Jagadeeswar Reddy, Denis Riendeau, M. David Percival, In Vivo Inhibition of Serine Protease Processing Requires a High Fractional Inhibition of Cathepsin C Molecular Pharmacology. ,vol. 73, pp. 1857- 1865 ,(2008) , 10.1124/MOL.108.045682
Yanyi Zhu, Jonathan E. Grob, Anup Patnaik, Branko Radetich, Michael Shultz, Marcus Rolf Dobler, Carboxyamine compounds and their use in the treatment of hdac dependent diseases ,(2006)
Bernhard Riniker, Walter Fuhrer, Peter Buhlmayer, Vittorio Rasetti, Substituted 5-amino-4-hydroxyvaleryl derivatives ,(1986)
Michael L. Moore, Ronggang Liu, David T. Fosbenner, Novel cathepsin c inhibitors and their use ,(2006)