Microfluidic method for measurement or detection involving cells or biomolecules

作者: Mehdi Javanmard , Ronald W. Davis , Michael N. Mindrinos , Janine A. Mok

DOI:

关键词:

摘要: Embodiments of the invention are related to microfluidic devices for detecting or determining concentration biomolecules in an analyte comprising: a channel, wherein surface said channel is fabricated be functionalized with at least one molecule selected interact biomolecule, being configured microsphere, microsphere same different biomolecule; second fluid communication first channel; system move containing through and channels; measure change electrical impedance optical microscopy across as moves channel. Other embodiments concern devices, methods making using.

参考文章(13)
Arthur Nitkowski, Michal Lipson, Integrated optofluidic system using microspheres ,(2010)
Christopher K. Fuller, Kodumudi S. Venkateswaran, Robin R. Miles, Impedance measurements for detecting pathogens attached to antibodies ,(2000)
Mehdi Javanmard, AmirAli H. Talasaz, Mohsen Nemat-Gorgani, Fabian Pease, Mostafa Ronaghi, Ronald W. Davis, Targeted cell detection based on microchannel gating Biomicrofluidics. ,vol. 1, pp. 044103- ,(2007) , 10.1063/1.2815760
Alan H. Diercks, Adrian Ozinsky, Carl L. Hansen, James M. Spotts, David J. Rodriguez, Alan Aderem, A microfluidic device for multiplexed protein detection in nano-liter volumes Analytical Biochemistry. ,vol. 386, pp. 30- 35 ,(2009) , 10.1016/J.AB.2008.12.012
H. Esfandyarpour, F. Pease, R. W. Davis, M. Javanmard, Electrical detection of proteins and DNA using bioactivated microfluidic channels: Theoretical and experimental considerations Journal of Vacuum Science & Technology B. ,vol. 27, pp. 3099- 3103 ,(2009) , 10.1116/1.3264675
Mehdi Javanmard, Amirali H. Talasaz, Mohsen Nemat-Gorgani, Fabian Pease, Mostafa Ronaghi, Ronald W. Davis, Electrical Detection Of Biomarkers Using Bioactivated Microfluidic Channels Lab on a Chip. ,vol. 9, pp. 1429- 1434 ,(2009) , 10.1039/B818872F
M. Waleed Shinwari, David Zhitomirsky, Imran A. Deen, P. R. Selvaganapathy, M. Jamal Deen, D. Landheer, Microfabricated Reference Electrodes and their Biosensing Applications Sensors. ,vol. 10, pp. 1679- 1715 ,(2010) , 10.3390/S100301679
Reto B. Schoch, Jongyoon Han, Philippe Renaud, Transport phenomena in nanofluidics Reviews of Modern Physics. ,vol. 80, pp. 839- 883 ,(2008) , 10.1103/REVMODPHYS.80.839
Jonathan S. Daniels, Nader Pourmand, Label-Free Impedance Biosensors: Opportunities and Challenges. Electroanalysis. ,vol. 19, pp. 1239- 1257 ,(2007) , 10.1002/ELAN.200603855
Mehdi Javanmard, Amirali H. Talasaz, Mohsen Nemat-Gorgani, David E. Huber, Fabian Pease, Mostafa Ronaghi, Ronald W. Davis, A Microfluidic Platform for Characterization of Protein–Protein Interactions IEEE Sensors Journal. ,vol. 9, pp. 883- 891 ,(2009) , 10.1109/JSEN.2009.2022558