Effects of pharmacologically-induced hypertension on myocardial ischemia and coronary hemodynamics in patients with fixed coronary obstruction.

摘要: Twenty patients with fixed coronary artery obstruction were studied during rapid atrial pacing and methoxamine infusion. During to heart rates of 142 +/- 4 (mean SEM) beats per minute sinus flow increased from 108 8 187 15 cc/min myocardial oxygen consumption by + 80 11%. infusion that raised arterial systolic pressure 196 5 mm Hg, similar increases in (to 179 13 cc/min) (+ 77 12%) occurred. Chest pain ischemic ST segment changes developed 17 14 respectively pacing, an incidence significantly greater (P less than 0.05) (6 3 patients). Myocardial lactate extraction which averaged 26 4% control was decreased 10 8% 24 7% methoxamine; the difference between decreases not significant. The data show at stress rate results more ischemia afterload.