1,2-cis Alkyl glycosides: straightforward glycosylation from unprotected 1-thioglycosyl donors
作者： Bo Meng , Zhenqian Zhu , David C. Baker
DOI: 10.1039/C4OB00626G
关键词:
摘要: A 1,2-cis-alkyl glycosidation protocol that makes use of unprotected phenyl 1-thioglycosyl donors is reported. Glycosylation various functionalized alcohols was accomplished in moderate to high yield and selectivity give the 1,2-cis-glycosides. In order quickly develop optimum glycosylation conditions, an FIA (flow injection analysis)–ESI-TOF-MS method developed enabled rapid quantitative evaluation on small scale. This methodology, coupled with NMR spectroscopy, allowed for overall reactions.
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