A facile and convenient chemoenzymatic synthesis of optically active O-(4-methoxyphenyl)-glycidol and 1,2-diacyl-sn-glycerol
作者： Ahmed Kamal , Mahendra Sandbhor , Ahmad Ali Shaik , M. Shaheer Malik
DOI: 10.1016/J.TETASY.2005.03.026
关键词:
摘要: A convenient preparation of the (R)- and (S)-enantiomers O-(4-methoxyphenyl)-glycidol by a one-pot reduction ketone 3 in situ lipase mediated resolution is described. Activated moist aluminium oxide presence Pseudomonas cepacia immobilized on ceramic particles (PS-C) has been found effective for transesterification leading to high degree enantioselectivity. These chiral glycidols were further used as precursor synthesis biologically important 1,2-O-diacyl-sn-glycerol under mild reaction conditions. The present method facile enantioselectivity when compared previously reported methods.
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