Symbolic sequence learning is associated with cognitive-affective profiles in female FMR1 premutation carriers

摘要: This study examines implicit sequence learning impairments that may indicate at-risk cerebellar profiles proposed to underlie some aspects of subtle cognitive and affective dysfunctions found among female fragile X mental retardation 1 (FMR1) premutation (PM)-carriers. A total 34 PM-carriers 33 age- intelligence-matched controls completed an symbolically primed serial reaction time task (SRTT) previously shown be sensitive involvement. Implicit scores indicated a preservation in both groups; however, demonstrated poorer through significantly elevated response latencies overall at each specific block within the symbolic SRTT. Group comparisons also revealed core deficit inhibition, alongside inattentive symptoms PM-carriers. Finally, strong significant associations were observed between poor SRTT performance executive, visuospatial deficits PM-carrier group. These remained even after controlling motor speed, not intelligence quotient-matched participants. The findings implicate non-motor networks subserving sequencing responses cognitive–affective phenotypes We contend offer clinical utility future pharmaceutical interventions