microRNA‑200a functions as a tumor suppressor by targeting FOXA1 in glioma
作者： Xiaofeng Chen , Kun Liu , Ping Yang , Weiping Kuang , Hongxing Huang
关键词:
摘要: microRNAs (miRs) serve primary roles in certain human malignancies; however, the detailed regulatory mechanism of miR-200a glioma progression is yet to be fully elucidated. The current study aimed assess expression as well cell proliferation, survival and invasion. RT-qPCR western blotting were performed examine mRNA protein expression. An MTT assay, an EdU incorporation proliferation assay a transwell utilized survival, results indicated that levels significantly reduced tissues compared with normal brain tissues. Levels also downregulated lines when those astrocyte cells. Furthermore, low was associated advanced glioma. overexpression inhibited Results identified FOXA1 target gene cells increased negatively correlated decreased mediated by eliminated inhibitory effects on invasion In conclusion, demonstrated functions acts tumor suppressor directly targeting may thus potential candidate for treatment
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