E-cadherin expression in renal cell cancer and its significance in metastasis and survival.

摘要: Decreased expression of E-cadherin (E-CD), a homotypic intercellular adhesion molecule, is considered to elicit detachment tumour cells from primary lesions, which the first stage metastasis. Since renal cell cancer (RCC) shows relatively high frequency metastasis, we focused our interest on E-CD in RCC and its clinicopathological implications. We examined normal kidney by immunohistochemical staining. In kidney, was localised distal tubules collecting ducts. RCC, 20 106 lesions (18.9%) expressed E-CD, whereas none showed positive staining for eight metastatic lesions. There statistically significant correlation between loss advanced stages RCC. Kaplan-Meier analysis better prognosis group with preserved than without (Cox-Mantel test, P = 0.022, average follow-up 32 months or until death). This study suggests that patients decreased may be associated resulting poor prognosis. However, lower other cancers, derived distribution kidney.