Vascular Biology of Magnesium: Implications in Cardiovascular Disease

摘要: Magnesium (Mg2+), an abundant intracellular divalent cation, plays essential role in numerous cellular functions. It is allosteric modulator of several proteins; controls nucleotide and protein synthesis; regulates Na+, K+, Ca2+ channels; critical for many enzymatic reactions, particularly those that are ATP-dependent [1–3]. Mg2+ stored mainly bone muscle with less than 1 % total body circulating the blood [4, 5]. homeostasis depends on balance between intestinal uptake renal excretion. The kidneys play important maintaining balance, acts as a buffer providing rapidly exchangeable pool to protect against acute changes plasma [6]. deficiency results from reduced dietary intake, malabsorption, or loss. Mammalian cells control levels within narrow range (0.70–1.1 mmol/l) by mechanisms, including intraorganelle compartmentalization, buffering, transmembrane transport through ion channels transporters.