Attenuation of luteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging in men.

摘要: To evaluate the impact of healthy aging on specific features endogeneous LH secretion and clearance, we applied deconvolution analysis to 24-h serum immunoradiometric concentration series obtained in normal men whose ages ranged from 21-73 yr. Deconvolution was employed quantitate number, amplitude, duration, mass individual secretory bursts underlying profiles, simultaneously estimate half-life men. Plasma total free testosterone estradiol concentrations body index (a measure relative adiposity) were studied as possible significant covariates age secretion. We found that a negative determinant burst amplitude (r = -0.519, P 0.013), positive predictor frequency +0.435, 0.043) basal rates +0.486, 0.029). Increasing also correlated positively with half-duration (duration secr...