Neuropsychological probes of fronto-limbic system dysfunction in schizophrenia. Olfactory identification and Wisconsin Card Sorting performance.

摘要: Abstract Schizophrenic patients and normal control subjects took the University of Pennsylvania Smell Identification Test (UPSIT) Wisconsin Card Sorting (WCST) as dual neuropsychological ‘probes’ orbitofrontal (OF) dorsolateral (DL) prefrontal function respectively. Patients were significantly impaired on both tasks compared to controls. UPSIT WCST performance uncorrelated in but positively correlated The lack correlation found suggests that may be tapping independent dysfunctions schizophrenia reflecting differential impairment fronto-limbic brain systems. Individual profiles preserved suggested three schizophrenic had OF dysfunction, five DL dysfunction seven a generalized (OF DL) frontal system dysfunction. reduced ability identify odors was largely many deficits or confounds typically associated with did not appear simply deficit. These data are preliminary require replication larger samples validation other measures