Identification of antioxidant and antimicrobial compounds from the oilseed crop Ricinus communis using a multiplatform metabolite profiling approach

摘要: Abstract Ricinus communis is an important oilseed crop, which widely used by traditional communities due to its medicinal properties. The extracts obtained from this plant are treat rhinitis, chest inflammation, bronchitis, dental caries, scabies, skin diseases, and infections in the digestive apparatus. Despite all properties, there a lack of studies that apply advanced chemical profiling techniques characterize diversity these extracts. objective study was detailed multiplatform-based metabolite approach identify antioxidant antimicrobial compounds R. Leaf, stem root were maceration hexane, ethyl acetate ethanol. Antioxidant activity assessed 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay total phenolic quantified Folin-Ciocalteu method. Antimicrobial against Bacillus subtilis, B. cereus, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonela choleraesuis, Candida albicans C. glabrata. Nuclear magnetic resonance, liquid chromatography–mass spectrometry, gas spectrometry profile (IC50) ranged 31.73 ± 2.59 571.74 ± 45.92 μg mL−1, whereas content varied 16.96 ± 0.30 135.06 ± 1.69 mg GAE/g extract. Extracts with ethanol showed greatest activity, highest content, along most promising For example, ethanolic extract leaves P. S. choleraesius, albicans, roots aeruginosa albicans. Three metabolites annotated NMR, 54 LC–MS, 36 GC–MS, included alkaloids, fatty acids, terpenes, compounds, steroids carotenoid derivatives. high levels alkaloid ricinine, seems contribute for activities This allowed us present Therefore, providing leads into discovery new active possibly development pharmaceuticals.