A novel long noncoding RNA Lnc-HC binds hnRNPA2B1 to regulate expressions of Cyp7a1 and Abca1 in hepatocytic cholesterol metabolism.

摘要: Cholesterol metabolism disorder in hepatocytes predicts a higher risk of metabolic syndrome (MetS). Long noncoding RNAs (lncRNAs) have emerged as critical players cellular cholesterol metabolism, but their functions are not systematically clarified. Here, we identified novel lncRNA named lnc-HC negatively regulating within through physical interaction with hnRNPA2B1. By further binding to the target messenger RNA Cyp7a1 or Abca1, lnc-HC-hnRNPA2B1 complex decreases expressions two genes that implicated excretion. knockdown can strongly recover vivo. In upstream pathway, is up-regulated by high transcription activator, CCAAT/enhancer-binding protein beta. Conclusion: These findings suggest subtle feed-forward regulation and define line evidence which lncRNAs modulate system at post-transcriptional level. (Hepatology 2016;64:58-72)