Division of labor during primary humoral immunity

摘要: B lymphocytes are often considered a homogenous population. However, cells in both mouse and humans comprised of distinct subpopulations that differ development, phenotype, function, microenvironmental niches. Much our understanding about how these different B-cells populations mount antibody responses has been derived from experimental findings models based on the use model antigens. These reductionist studies performed over decades have invaluable defining parameters B-cell response to types antigens also now known significant manner bona fide physiological pathogens, precisely subsets divide labor primary humoral immune defense pathogens is less well understood. While there no absolutes this area, recurring themes roles arms response. This review provides an overview rules govern roles, exceptions break rules, used define them.