Role of TRAF6 in the immune system

作者: Yongwon Choi

DOI: 10.1007/0-387-24180-9_11

关键词:

摘要: TRAF6 is a member of the TNF receptor associated factor (TRAF) family, members which are important for signaling induced by variety family members. was initially identified as adapter CD40, but has subsequently been shown to be critical interleukin-1 receptor~Toll-like (IL-lR/TLR) family. Therefore, represents central point con- vergence signal transduction TNFR and IL-lR/TLR superfamilies, thus plays role in regulation innate immune responses. Considering importance IL-RITLR system, extent regulates physiology immunity, well connection between adaptive responses, great interest. Here we have described potential regulating dendritic cell fates.

参考文章(57)
Hong Ye, Young Chul Park, Jee Y. Chung, Hao Wu, All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction Journal of Cell Science. ,vol. 115, pp. 679- 688 ,(2002) , 10.1242/JCS.115.4.679
Hiroyasu Nakano, Hideo Oshima, Winston Chung, Laura Williams-Abbott, Carl F. Ware, Hideo Yagita, Ko Okumura, TRAF5, an Activator of NF-κB and Putative Signal Transducer for the Lymphotoxin-β Receptor Journal of Biological Chemistry. ,vol. 271, pp. 14661- 14664 ,(1996) , 10.1074/JBC.271.25.14661
Young-Yun Kong, Hiroki Yoshida, Ildiko Sarosi, Hong-Lin Tan, Emma Timms, Casey Capparelli, Sean Morony, Antonio J. Oliveira-dos-Santos, Gwyneth Van, Annick Itie, Wilson Khoo, Andrew Wakeham, Colin R. Dunstan, David L. Lacey, Tak W. Mak, William J. Boyle, Josef M. Penninger, OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis Nature. ,vol. 397, pp. 315- 323 ,(1999) , 10.1038/16852
Cees Van Kooten, Jacques Banchereau, CD40-CD40 LIGAND : A MULTIFUNCTIONAL RECEPTOR-LIGAND PAIR Advances in Immunology. ,vol. 61, pp. 1- 77 ,(1996) , 10.1016/S0065-2776(08)60865-2
N. Itoh, S. Nagata, A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. Journal of Biological Chemistry. ,vol. 268, pp. 10932- 10937 ,(1993) , 10.1016/S0021-9258(18)82075-0
Shizuo Akira, Kiyoshi Takeda, Tsuneyasu Kaisho, Toll-like receptors: critical proteins linking innate and acquired immunity Nature Immunology. ,vol. 2, pp. 675- 680 ,(2001) , 10.1038/90609
Jacques Banchereau, Ralph M. Steinman, Dendritic cells and the control of immunity Nature. ,vol. 392, pp. 245- 252 ,(1998) , 10.1038/32588
John Paul Ridge, Francesca Di Rosa, Polly Matzinger, A conditioned dendritic cell can be a temporal bridge between a CD4 + T-helper and a T-killer cell Nature. ,vol. 393, pp. 474- 478 ,(1998) , 10.1038/30989
Brian R. Wong, Regis Josien, Yongwon Choi, TRANCE is a TNF family member that regulates dendritic cell and osteoclast function. Journal of Leukocyte Biology. ,vol. 65, pp. 715- 724 ,(1999) , 10.1002/JLB.65.6.715
J. Li, I. Sarosi, X.-Q. Yan, S. Morony, C. Capparelli, H.-L. Tan, S. McCabe, R. Elliott, S. Scully, G. Van, S. Kaufman, S.-C. Juan, Y. Sun, J. Tarpley, L. Martin, K. Christensen, J. McCabe, P. Kostenuik, H. Hsu, F. Fletcher, C. R. Dunstan, D. L. Lacey, W. J. Boyle, RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 1566- 1571 ,(2000) , 10.1073/PNAS.97.4.1566