Evaluation of the chemopreventive effects of Hypericum perforatum L on DMBA-applied rat oral mucosa.
作者： Nurdan Saraç , Aysel Uğur , Ayşegül Fırat , Hasan Serdar Öztürk , Fevziye Figen Kaymaz
DOI: 10.1016/J.ARCHORALBIO.2021.105139
关键词:
摘要: Abstract Objective Hypericum perforatum L also known as St. John’s wort is to have many beneficial properties for the organism including its antioxidant and anticancer activities. It shown antiproliferative cytotoxic effects against various cancer cell lines. The purpose of this study was investigate on 7,12-dimethylbenz(a)anthracene-induced rat oral squamous carcinoma model. Design in vitro determined an extract prepared. Thirty Wistar male rats were divided randomly into 4 groups (Control group, DMBA HP + DMBA HP group). defense mechanisms tissue blood samples evaluated biochemically immunohistochemically, carcinomatous changes connective investigated immunohistochemically epithelial histopathologically. Results revealed inhibitory some enzymes (catalase, glutathione peroxidase). Immunohistochemical evaluations no invasive tissue. demonstrated chemopreventive although it did not prevent altogether. Conclusions a promising agent further studies are needed order evaluate full potential plant.
sci-hub.st 参考文章(59)
J. H. Bennett, M. J. Morgan, S. A. Whawell, P. Atkin, P. Roblin, J. Furness, P. M. Speight, Metalloproteinase expression in normal and malignant oral keratinocytes: stimulation of MMP‐2 and ‐9 by scatter factor European Journal of Oral Sciences. ,vol. 108, pp. 281- 291 ,(2000) , 10.1034/J.1600-0722.2000.108004281.X
Kalu U. E. Ogbureke, Christopher Bingham, Overview of Oral Cancer InTech. ,(2012) , 10.5772/30520
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Christoph M Schempp, Vladimir Kirkin, Birgit Simon-Haarhaus, Astrid Kersten, Judit Kiss, Christian C Termeer, Bernhard Gilb, Thomas Kaufmann, Christoph Borner, Jonathan P Sleeman, Jan C Simon, Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis. Oncogene. ,vol. 21, pp. 1242- 1250 ,(2002) , 10.1038/SJ.ONC.1205190
Sheetal Korde Choudhari, Minal Chaudhary, Amol R. Gadbail, Aparna Sharma, Satyajit Tekade, Oxidative and antioxidative mechanisms in oral cancer and precancer: a review. Oral Oncology. ,vol. 50, pp. 10- 18 ,(2014) , 10.1016/J.ORALONCOLOGY.2013.09.011
S. F. Chandler, J. H. Dodds, The effect of phosphate, nitrogen and sucrose on the production of phenolics and solasodine in callus cultures of solanum laciniatum Plant Cell Reports. ,vol. 2, pp. 205- 208 ,(1983) , 10.1007/BF00270105
Jingwen Yi, Xiaoguang Yang, Lihua Zheng, Guang Yang, Luguo Sun, Yongli Bao, Yin Wu, Yanxin Huang, Chunlei Yu, Shao-Nian Yang, Yuxin Li, Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio. Bioscience Reports. ,vol. 35, pp. 1- 13 ,(2015) , 10.1042/BSR20150028
Subramanian Balakrishnan, Venugopal P. Menon, Shanmugam Manoharan, Ferulic Acid Inhibits 7,12-Dimethylbenz[α]anthracene-Induced Hamster Buccal Pouch Carcinogenesis Journal of Medicinal Food. ,vol. 11, pp. 693- 700 ,(2008) , 10.1089/JMF.2007.0103
L Loro, Decreased expression of bcl-2 in moderate and severe oral epithelia dysplasias. Oral Oncology. ,vol. 38, pp. 691- 698 ,(2002) , 10.1016/S1368-8375(02)00002-7
Nagarethinam Baskaran, Shanmugam Manoharan, Subramanian Balakrishnan, Pachaiappan Pugalendhi, Chemopreventive potential of ferulic acid in 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague-Dawley rats. European Journal of Pharmacology. ,vol. 637, pp. 22- 29 ,(2010) , 10.1016/J.EJPHAR.2010.03.054