Meningioma Treated with Interferon-α, Evaluated with [11C]-l-Methionine Positron Emission Tomography

摘要: Purpose: In meningioma patients with postoperative residual masses, recurrent or primarily inoperable tumors, positron emission tomography (PET) [ 11 C]-l-methionine was used to evaluate treatment efficacy of IFN-α. Experimental Design : Twelve were treated IFN-α at a dose 1.5–5 million IU s.c. daily. PET, computed tomography, and/or magnetic resonance imaging performed in all before and, regular intervals, during treatment. The ratio tumor hot-spot uptake cerebellar cortex calculated. This estimates the relative methionine accumulation and presumably proliferative activity tumor. Results: During treatment, PET demonstrated mean percentage reduction (MRelR) 22.3% meningiomas. nine who considered responders, defined as positive MRelR, MRelR 30.4%. For three nonresponders, negative −1.8%. Three followed for long time: two 8 years one patient 4 6 months; are still on IFN. volumes these tumors constant showed slight decrease. No correlation found between histopathological diagnosis (PAD) WHO grading I–III meningiomas response Conclusions judged useful method predict which suitable long-term also finding. five from 9 months years, seemed be an effective oncostatic drug. clinical usefulness IFN-α, taking adverse reactions into account, must evaluated larger series patients.