Temozolomide for treatment of brain metastases: A review of 21 clinical trials
作者： Wei Zhu
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摘要: Brain metastases from solid tumours are associated with poor prognosis despite aggressive treatment. Temozolomide can be used for the treatment of glioblastoma multiforme as well melanoma. It has also been shown to have activity in patients brain various malignancies, since it cross blood-brain barrier. To better understand efficacy temozolomide metastases, we carried out a review 21 published clinical trials determine whether would benefit tumours. Information regarding complete response, partial stable disease, objective response and rate were collected assess outcomes. A modest therapeutic effect was observed when single agent, however, combination whole-brain radiotherapy and/or other anticancer drugs exhibited encouraging activity. Thus, future high quality studies warranted confirm our findings.
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