Mechanisms of Selective Autophagy in Normal Physiology and Cancer.

摘要: Selective autophagy is critical for regulating cellular homeostasis by mediating lysosomal turnover of a wide variety substrates including proteins, aggregates, organelles, and pathogens via growing class molecules termed selective receptors. The molecular mechanisms receptor action regulation are complex. receptors link their bound cargo to the autophagosomal membrane interacting with lipidated ATG8 proteins (LC3/GABARAP) that intimately associated autophagosome membrane. signals recognize diverse but recognition can be broadly grouped into two classes, ubiquitin-dependent versus ubiquitin-independent. roles post-translational modification in these pathways response stimuli an active area research. Here we will review recent advances identification regulatory mechanisms. Given its importance maintaining homeostasis, disruption lead disease neurodegeneration cancer. role cancer complex as mediate promotion or inhibition tumorigenesis. also specific focus on