Increased expression of the lncRNA PVT1 is associated with poor prognosis in pancreatic cancer patients.

摘要: AIM Long non-coding RNA PVT1 (lncRNA PVT1) has been identified and it plays an oncogenic role in various human cancers. However, its roles pancreatic cancer remain unclear. The aim of this paper was to explore the expression levels relationship with survival patients ductal adenocarcinoma (PDAC) establish significance development progression PDAC. METHODS In study, quantitative real-time polymerase chain reaction performed analyze lncRNA paired PDAC adjacent nontumor tissues. association clinicopathological features analyzed. Kaplan-Meier analysis overall rate Univariate multivariate Cox regression analyses were carried out prognostic expression. RESULTS study results showed that significantly increased tissues compared associated clinical stage N-classification (P<0.05). Patients high level had shorter times those low suggested might be independent factor for poor CONCLUSION findings correlated tumor progression, a potential molecular biomarker predicting prognosis