Cryoballoon versus radiofrequency ablation for paroxysmal atrial fibrillation: a meta-analysis of randomized controlled trials

摘要: The aim of this study was to evaluate the clinical efficacy and safety outcomes treatment with cryoballoon (CB) compared traditional irrigated radiofrequency ablation (RF) for pulmonary vein isolation (PVI) in patients paroxysmal atrial fibrillation (pAF) refractory antiarrhythmic drug therapy (AAD). We conducted a systemic review find include more than two randomized controlled trials (RCTs) at least 20 each CB RF groups. Thereafter, we performed meta-analysis compare primary including 1 year free from AF, complications re-ablation procedures. Additionally, evaluated procedure time fluoroscopy duration both Risk bias individual studies across assessed using Cochrane methods. Two reviewers extracted data risk bias. Primary outcome were point after procedure. random-effects model used calculate odds ratio 95% confidence interval. Data sources utilized PubMed CENTRAL databases up 16 June 2016. Included RCTs adults pAF AAD which therapy, 1st 2nd generation CB, therapy. Clinical RCT AF-free survival, complication rates, re-ablations, time. systematic identified four that reported on comparative involving 1284 patients. Our demonstrated had non-significant higher success rate (OR 1.13; CI 0.72–1.77). However, our showed relatively group 1.20; 0.58–2.52). Furthermore, associated non-significant, shorter marginally prolonged comparison treatment. revealed further evidence is an equally effective alternative standard slightly, freedom AF