World Workshop on Oral Medicine VI: a systematic review of the treatment of mucocutaneous pemphigus vulgaris

摘要: Objective To determine the efficacy and safety of interventions for pemphigus vulgaris (PV). Study Design We conducted a systematic review from 2003 to 2013 according Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or clinical (CCTs) observational studies were along with diagnosis confirmed by clinical, histopathologic, immunofluorescence criteria. Primary outcomes disease remission mortality; several relevant secondary also included. Results Fourteen RCTs CCTs 110 included in final analyses. demonstrated considerable heterogeneity outcome measures, all had high risk bias at least 1 8 domains. Of studies, 96.8% (120) described use oral corticosteroids. Azathioprine mycophenolate–mofetil most commonly cited treatments. An increasing number biologic therapies (rituximab, intravenous immunoglobulin [IVIg]). Evidence supporting recent comprehensive treatment guidelines was reviewed. Conclusions found persisting wide variations practice inadequate quality research optimal PV treatment.