作者: Thomas J. Balkin , Gary H. Kamimori , Gregory Belenky , Cynthia Marie Lajambe
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摘要: Introduction: Caffeine is widely used to reverse alertness and performance decrements. However, caffeine's effects on subsequent recovery sleep post-recovery are not well documented and, therefore, were evaluated. Methods: Six habitually low (LC: ≤ 100 mg . d - 1 ) three high (HC: ≥ 400 caffeine users completed a randomized crossover design. After 20 h of wakefulness, repeated doses gum [0 (placebo) mg, (low dose) or 300 (high mg] administered at 03:00, 05:00, 07:00. At 10:00 (27 deprivation) subjects slept for 8 h, followed by Psychomotor Vigilance Task (PVT) administration 33 65 min post-awakening. Results: Low dose increased stage minutes only. impaired maintenance (reduced total time/increased wake) reduced depth (increased minutes/percentage slow-wave (SWS) latency, SWS during the first third period). With caffeine, LC had less percentage as compared with HC users. The 2 placebo caffeine. habitual use did influence PVT performance. Discussion: exerts mild deleterious dose-response following deprivation, primarily early in period, potential from these after sufficient suggested lack deficits. Habitual appears minimally reduce effects.