A Genome-Wide Association Meta-Analysis of Prognostic Outcomes Following Cognitive Behavioural Therapy in Individuals With Anxiety and Depressive Disorders

作者: Christopher Rayner , Jonathan RI Coleman , Kirstin L Purves , John Hodsoll , Kimberley Goldsmith

DOI: 10.1038/S41398-019-0481-Y

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摘要: Major depressive disorder and the anxiety disorders are highly prevalent, disabling moderately heritable. Depression also comorbid have a strong genetic correlation (rg ≈ 1). Cognitive behavioural therapy is leading evidence-based treatment but has variable outcomes. Currently, there no predictors of outcome. Therapygenetics research aims to identify prognosis following therapy. We performed genome-wide association meta-analyses symptoms cognitive in adults with (n = 972), major (n = 832) children (n = 920; meta-analysis n = 2724). estimated variance outcomes that could be explained by common variants (h2SNP) polygenic scoring was used examine associations between psychopathology, personality learning. No single nucleotide polymorphisms were strongly associated significant estimate h2SNP obtained, suggesting heritability outcome smaller than our analysis powered detect. Polygenic failed detect overlap or This study largest therapygenetics date. Results consistent previous, similarly studies complex traits.

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