Analysis of differentially expressed circular RNAs for the identification of a coexpression RNA network and signature in colorectal cancer.
作者： Zheying Zhang , Na Song , Yongxia Wang , Jiateng Zhong , Tengteng Gu
DOI: 10.1002/JCB.27928
关键词:
摘要: Circular RNAs (circRNAs) play an important regulatory role in tumorigenesis. The aim of the present study was to analyze circRNA expression network and elucidate its potential implications colorectal cancer (CRC). profile analyzed CRC tissues by RNA sequencing, functions differentially expressed genes were Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analysis. predicted with bioinformatics. On basis results, we identified 23 circRNAs CRC; GO KEGG analyses demonstrated that changes mainly associated regulation biological metabolic processes through binding other molecules. In addition, based on coexpression network, a hub circRNA, hsa_circ_0009022. Subsequently, results sequencing confirmed reverse transcription-quantitative polymerase chain reaction, hsa_circ_0000826 found be downregulated CRC. Taken together, these findings indicate set may serve as candidate diagnostic biomarker promising therapeutic target
sci-hub.se 参考文章(21)
Yan Li, Qiupeng Zheng, Chunyang Bao, Shuyi Li, Weijie Guo, Jiang Zhao, Di Chen, Jianren Gu, Xianghuo He, Shenglin Huang, Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Research. ,vol. 25, pp. 981- 984 ,(2015) , 10.1038/CR.2015.82
Shibin Qu, Xisheng Yang, Xiaolei Li, Jianlin Wang, Yuan Gao, Runze Shang, Wei Sun, Kefeng Dou, Haimin Li, Circular RNA: A new star of noncoding RNAs Cancer Letters. ,vol. 365, pp. 141- 148 ,(2015) , 10.1016/J.CANLET.2015.06.003
Xintian You, Irena Vlatkovic, Ana Babic, Tristan Will, Irina Epstein, Georgi Tushev, Güney Akbalik, Mantian Wang, Caspar Glock, Claudia Quedenau, Xi Wang, Jingyi Hou, Hongyu Liu, Wei Sun, Sivakumar Sambandan, Tao Chen, Erin M Schuman, Wei Chen, Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity Nature Neuroscience. ,vol. 18, pp. 603- 610 ,(2015) , 10.1038/NN.3975
Reut Ashwal-Fluss, Markus Meyer, Nagarjuna Reddy Pamudurti, Andranik Ivanov, Osnat Bartok, Mor Hanan, Naveh Evantal, Sebastian Memczak, Nikolaus Rajewsky, Sebastian Kadener, circRNA Biogenesis Competes with Pre-mRNA Splicing Molecular Cell. ,vol. 56, pp. 55- 66 ,(2014) , 10.1016/J.MOLCEL.2014.08.019
Sebastian Memczak, Marvin Jens, Antigoni Elefsinioti, Francesca Torti, Janna Krueger, Agnieszka Rybak, Luisa Maier, Sebastian D. Mackowiak, Lea H. Gregersen, Mathias Munschauer, Alexander Loewer, Ulrike Ziebold, Markus Landthaler, Christine Kocks, Ferdinand le Noble, Nikolaus Rajewsky, Circular RNAs are a large class of animal RNAs with regulatory potency Nature. ,vol. 495, pp. 333- 338 ,(2013) , 10.1038/NATURE11928
Giovanni Scardoni, Michele Petterlini, Carlo Laudanna, Analyzing biological network parameters with CentiScaPe Bioinformatics. ,vol. 25, pp. 2857- 2859 ,(2009) , 10.1093/BIOINFORMATICS/BTP517
Mark D Robinson, Davis J McCarthy, Gordon K Smyth, None, edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. ,vol. 26, pp. 139- 140 ,(2010) , 10.1093/BIOINFORMATICS/BTP616
Yuan Gao, Jinfeng Wang, Fangqing Zhao, CIRI: an efficient and unbiased algorithm for de novo circular RNA identification. Genome Biology. ,vol. 16, pp. 4- 4 ,(2015) , 10.1186/S13059-014-0571-3
Mei Guo, Jun Dou, Advances and perspectives of colorectal cancer stem cell vaccine. Biomedicine & Pharmacotherapy. ,vol. 76, pp. 107- 120 ,(2015) , 10.1016/J.BIOPHA.2015.10.027
William W. Du, Weining Yang, Elizabeth Liu, Zhenguo Yang, Preet Dhaliwal, Burton B. Yang, Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 Nucleic Acids Research. ,vol. 44, pp. 2846- 2858 ,(2016) , 10.1093/NAR/GKW027