Physiological Functions of Osteoblast Lineage and T Cell–Derived RANKL in Bone Homeostasis

摘要: The cytokine RANKL is essential for osteoclast development in bone. cellular sources of support generation under various pathophysiological conditions have remained unclear, however. Here we show that inactivation Rankl specifically osteoblast lineage cells mice with the use an Osterix-Cre transgene results typical osteopetrosis trabecular compartment tibia, phenotype being progressively less marked femur and vertebrae. In contrast to its effects on bone, deficiency resulted thinning femoral cortex association suppression bone formation during modeling process. Ablation T a moderate but significant increase tibial Mice were protected from loss induced by ovariectomy as well joint destruction associated arthritis, whereas did not confer such protection. Finally, inducible deletion selectively osteoblasts 6 12 weeks age mass reduced resorption formation. Our thus suggest produced contributes vivo.