Overview of hemodynamic and non-hemodynamic factors associated with left ventricular hypertrophy

摘要: The role of the heart in hypertension has finally emerged as a major issue cardiovascular concern by clinician, physiologist, pharmacologist, biochemist, and molecular biologist. This discussion provides an overview present state knowledge current areas investigation this active area broad interest. Generally, these relate to: participation (e.g. hemodynamic, humoral, autocrine/paracrine); adaptive response (i.e. hemodynamic); non-hemodynamic relationships (vis-a-vis, age, race, gender, coexistent disease); thoughts on mechanisms so-called regression left ventricular hypertrophy. Several antihypertensive classes compounds are characterized decreasing cardiac mass wall thicknesses. angiotensin converting enzyme inhibitors included among agents; their physiological effects producing “regression” under study responsible for changes. These concerns no longer incidental or theoretical interest but have impact selection therapy management patient with hypertension. Thus, may participate actively pathogenesis maintenance disease; it adapts to vascular disease hemodynamically; regard both positive beneficial well negative implications independent risk factor. latter should be explored great depth before conclusions made respect long-term heart.