The burden of gastrointestinal and liver diseases, 2006.

摘要: BACKGROUND Digestive and liver diseases are a source of significant morbidity, mortality, health-care costs for the U.S. population. An annual report toll these could be helpful to clinicians, policymakers, researchers. AIM To describe epidemiology gastrointestinal in United States using data from privately publicly held databases. METHODS We collected National Center Health Statistics, Ambulatory Medical Care Survey, Inpatient Sample, Centers Disease Control Prevention, Cancer Institute, as well proprietary pharmaceutical databases construct on impact compiled information causes death, hospitalization, clinic visits, cancer incidence, mortality infectious disease incidence databases, extracted specific diseases. Because high associated with medications used treat diseases, we also include this year's special section pharmacoepidemiology pharmacoeconomics. RESULTS Colorectal continues leading cause GI-related although indicate downward trend deaths. Abdominal pain, diarrhea, vomiting, nausea most common GI symptoms precipitating visit physician, GERD is diagnosis given office visits. Chest pain not specified cardiac origin inpatient admission possibly related disease, cholelithiasis pancreatitis following. Americans spend excess US dollars 10 billion/yr proton pump inhibitors (PPIs), two top five selling drugs PPIs. Trends PPI use demonstrate turbulent changes, likely reflecting both new drug entries into field, marketing. The number prescriptions/yr has doubled since 1999. Twenty-three among 200 generic States. CONCLUSIONS Gastrointestinal contributors expenditures