Tissue response to fast-setting calcium phosphate cement in bone.

摘要: Fast-setting calcium phosphate cement (FSCPC) is a promising new bioactive with significantly short setting time (approximately 5-6 min) compared to conventional (c-CPC) (30-60 at physiologic temperatures. As result of its ability set quickly, it applicable in surgical procedures where fast required. In this study, FSCPC was implanted rat tibiae evaluate tissue response and biocompatibility. converted hydroxyapatite (HAP) bone faster than c-CPC the first 6 h. By 24 h, significant amounts both had been HAP. The conversion into HAP further proceeded gradually, reaching 100% within 8 weeks. Infrared spectroscopic analysis disclosed deposition B-type carbonate apatite, which biological apatite contained human dentin or bone, on surface FSCPC. Histologically, showed similar that c-CPC. A slight inflammatory reaction observed soft apposed cements early period, formed along adjacent bone. However, no resorption either by osteoclasts macrophages We conclude superior clinical applications oral maxillofacial, orthopedic, plastic, reconstructive surgery, since shows higher mechanical strength period are required these procedures, as well osteoconductivity excellent biocompatibility