CMS-dependent prognostic impact of KRAS and BRAFV600E mutations in primary colorectal cancer
作者： J. Smeby , A. Sveen , M.A. Merok , S.A. Danielsen , I.A. Eilertsen
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摘要: Background The prognostic impact of KRAS and BRAFV600E mutations in primary colorectal cancer (CRC) varies with microsatellite instability (MSI) status. gene expression-based consensus molecular subtypes (CMSs) CRC define molecularly clinically distinct subgroups, represent a novel stratification framework biomarker analysis. We investigated the value these within CMS groups. Patients methods Totally 1197 tumors from Norwegian series stage I-IV were analyzed for MSI mutation status hotspots (codons 12, 13 61) BRAF (codon 600). A subset was expression confident classification obtained 317 samples. This cohort expanded clinical data, including classification, 514 patients publically available dataset GSE39582. Gene signatures associated used to evaluate differential on among Results both inferior 5-year overall survival (OS) exclusively MSS (BRAFV600E versus KRAS/BRAF wild-type: Hazard ratio (HR) 2.85, P < 0.001; HR 1.30, P = 0.013). BRAFV600E-mutated strongly enriched metastatic disease CMS1, leading negative this subtype (OS: 7.73, P = 0.001). In contrast, poor prognosis limited CMS2/CMS3 epithelial-like profiles 1.51, P = 0.011). subtype-specific associations substantiated by effects according group. Conclusions are CMS1 tumors, subtype. adverse outcome epithelial (CMS2/CMS3) tumors.
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G. I Meling, P Laurent-Puig, B. J Iacopetta, R Glaesener, O. P. F Clausen, F Al-Mulla, W Giaretti, V. J Bubb, A. F. P. M de Goeij, G Gaudernack, T Ohkusa, P Quirke, A Rapallo, N Hawkins, R Rosell, T. O Rognum, S. N Andersen, R Smith, J Costa, R Ward, I Hoffmann, T Fujimori, D Cunningham, D Morton, C. T Croke, J Oates, X. F Sun, S Bell, P. A Clarke, S. T Wang, J Breivik, O Muller, A. R Norman, J. W Arends, M Pauly, D Dillon, H. J. N Andreyev, S. D Finkelstein, A. J Senagore, C. N Hall, K Wilkinson, N Lees, N. R Cruickshank, H. S Goh, D Snary, E Jullian, C Valavanis, L Losi, A Russo, H. M Rabes, J Piris, S Wadler, Y Ono, T Azuma, A Font, C Zietz, M Beranek, J. C Fox, S. A Halter, R Benamouzig, B. R Dix, H Zhang, C Faber, K Omura, V. E Pricolo, C Troungos, K Krtolica, J Benhattar, J. W. C Ho, N. Urosevic, T Lovig, D. P O'Donoghue, J. S Thebo, P De Angelis, J. Q Lee, J Young, Bazan, P Jandik, S Olschwang, S. T Yuen, T Walsh, S Malik, M Tanaka, Kirsten ras mutations in patients with colorectal cancer : the ‘RASCAL II’ study Faculty of Health; Institute of Health and Biomedical Innovation. ,vol. 85, pp. 692- 696 ,(2001)
Ryan B. Corcoran, Chloe E. Atreya, Gerald S. Falchook, Eunice L. Kwak, David P. Ryan, Johanna C. Bendell, Omid Hamid, Wells A. Messersmith, Adil Daud, Razelle Kurzrock, Mariaelena Pierobon, Peng Sun, Elizabeth Cunningham, Shonda Little, Keith Orford, Monica Motwani, Yuchen Bai, Kiran Patel, Alan P. Venook, Scott Kopetz, Combined BRAF and MEK inhibition with dabrafenib and trametinib in BRAF V600-Mutant colorectal cancer Journal of Clinical Oncology. ,vol. 33, pp. 4023- 4031 ,(2015) , 10.1200/JCO.2015.63.2471
Justin Guinney, Rodrigo Dienstmann, Xin Wang, Aurélien De Reynies, Andreas Schlicker, Charlotte Soneson, Laetitia Marisa, Paul Roepman, Gift Nyamundanda, Paolo Angelino, Brian M Bot, Jeffrey S Morris, Iris M Simon, Sarah Gerster, Evelyn Fessler, Felipe De Sousa E Melo, Edoardo Missiaglia, Hena Ramay, David Barras, Krisztian Homicsko, Dipen Maru, Ganiraju C Manyam, Bradley Broom, Valerie Boige, Beatriz Perez-Villamil, Ted Laderas, Ramon Salazar, Joe W Gray, Douglas Hanahan, Josep Tabernero, Rene Bernards, Stephen H Friend, Pierre Laurent-Puig, Jan Paul Medema, Anguraj Sadanandam, Lodewyk Wessels, Mauro Delorenzi, Scott Kopetz, Louis Vermeulen, Sabine Tejpar, None, The consensus molecular subtypes of colorectal cancer Nature Medicine. ,vol. 21, pp. 1350- 1356 ,(2015) , 10.1038/NM.3967
Wade S. Samowitz, Carol Sweeney, Jennifer Herrick, Hans Albertsen, Theodore R. Levin, Maureen A. Murtaugh, Roger K. Wolff, Martha L. Slattery, Poor Survival Associated with the BRAF V600E Mutation in Microsatellite-Stable Colon Cancers Cancer Research. ,vol. 65, pp. 6063- 6069 ,(2005) , 10.1158/0008-5472.CAN-05-0404
Marianne Berg, Stine A. Danielsen, Terje Ahlquist, Marianne A. Merok, Trude H. Ågesen, Morten H. Vatn, Tom Mala, Ole H. Sjo, Arne Bakka, Ingvild Moberg, Torunn Fetveit, Øystein Mathisen, Anders Husby, Oddvar Sandvik, Arild Nesbakken, Espen Thiis-Evensen, Ragnhild A. Lothe, DNA Sequence Profiles of the Colorectal Cancer Critical Gene Set KRAS-BRAF-PIK3CA-PTEN-TP53 Related to Age at Disease Onset PLoS ONE. ,vol. 5, pp. e13978- ,(2010) , 10.1371/JOURNAL.PONE.0013978
Mathias Uhlén, Linn Fagerberg, Björn M Hallström, Cecilia Lindskog, Per Oksvold, Adil Mardinoglu, Åsa Sivertsson, Caroline Kampf, Evelina Sjöstedt, Anna Asplund, IngMarie Olsson, Karolina Edlund, Emma Lundberg, Sanjay Navani, Cristina Al-Khalili Szigyarto, Jacob Odeberg, Dijana Djureinovic, Jenny Ottosson Takanen, Sophia Hober, Tove Alm, Per-Henrik Edqvist, Holger Berling, Hanna Tegel, Jan Mulder, Johan Rockberg, Peter Nilsson, Jochen M Schwenk, Marica Hamsten, Kalle Von Feilitzen, Mattias Forsberg, Lukas Persson, Fredric Johansson, Martin Zwahlen, Gunnar Von Heijne, Jens Nielsen, Fredrik Pontén, Tissue-based map of the human proteome Science. ,vol. 347, pp. 1260419- 1260419 ,(2015) , 10.1126/SCIENCE.1260419
Toshiaki Watanabe, Takashi Kobunai, Yoko Yamamoto, Keiji Matsuda, Soichiro Ishihara, Keijiro Nozawa, Hisae Iinuma, Hiroki Ikeuchi, Kiyoshi Eshima, Differential gene expression signatures between colorectal cancers with and without KRAS mutations: Crosstalk between the KRAS pathway and other signalling pathways European Journal of Cancer. ,vol. 47, pp. 1946- 1954 ,(2011) , 10.1016/J.EJCA.2011.03.029
M.A. Merok, T. Ahlquist, E.C. Røyrvik, K.F. Tufteland, M. Hektoen, O.H. Sjo, T. Mala, A. Svindland, R.A. Lothe, A. Nesbakken, Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series Annals of Oncology. ,vol. 24, pp. 1274- 1282 ,(2013) , 10.1093/ANNONC/MDS614
Anurag Singh, Patricia Greninger, Daniel Rhodes, Louise Koopman, Sheila Violette, Nabeel Bardeesy, Jeff Settleman, A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival Cancer Cell. ,vol. 15, pp. 489- 500 ,(2009) , 10.1016/J.CCR.2009.03.022
Cecilia Guastadisegni, Mauro Colafranceschi, Laura Ottini, Eugenia Dogliotti, Microsatellite instability as a marker of prognosis and response to therapy: a meta-analysis of colorectal cancer survival data. European Journal of Cancer. ,vol. 46, pp. 2788- 2798 ,(2010) , 10.1016/J.EJCA.2010.05.009