Hyaluronate-Cell Interactions in Morphogenesis and Tumorigenesis
作者： B. P. Toole , C. B. Knudson , W. Knudson , R. L. Goldberg , G. Chi-Rosso
DOI: 10.1007/978-3-642-71837-3_21
关键词:
摘要: Hyaluronate is a ubiquitous component of the extracellular matrices in which embryonic mesenchymal cells migrate and proliferate. It also present tissues at early stages healing, remodelling regeneration (for reviews, see Toole, 1976, 1981; Toole et al., 1984). high molecular weight, negatively charged glycosaminoglycan consisting repeating disaccharide units N-acetylglucosamine glucuronate. Its physical chemical properties contribute to an milieu important both structural integrity above morphogenetic processes that take place within them. The contribution hyaluronate due least two factors: i) its remarkable hydrodynamic properties; ii) modes interaction with cell surface. latter upon this brief review will mainly focus.
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