Metabolic Hallmarks of Metastasis Formation.

摘要: Metastasis to distant organs is a predictor of poor prognosis. Therefore, it paramount importance understand the mechanisms that impinge on different steps metastatic cascade. Recent work has revealed particular metabolic pathways are rewired in cancer cells support their transition through cascade, resulting formation secondary tumors organs. Indeed, rewiring induces signaling during initial invasion, circulating depend enhanced antioxidant defenses, and colonizing organ require increased ATP production. Moreover, local environment niche dictates rely on. Here we describe associated with distinct metastasis formation.