Evolution of Sex Chromosome Dosage Compensation in Animals: A Beautiful Theory, Undermined by Facts and Bedeviled by Details
作者： Liuqi Gu , James R Walters
DOI: 10.1093/GBE/EVX154
关键词:
摘要: Many animals with genetic sex determination harbor heteromorphic chromosomes, where the heterogametic has half gene dose of homogametic sex. This imbalance, if reflected in abundance transcripts or proteins, potential to deleteriously disrupt interactions between X-linked and autosomal loci Classical theory predicts that molecular mechanisms will evolve provide dosage compensation recovers expression levels comparable ancestral prior chromosome divergence. Such compensating may also, secondarily, result balanced sex-linked males females. However, numerous recent studies addressing (SCDC) a diversity have yielded surprising array patterns concerning sex, as well balance sexes. These results substantially contradict longstanding theory, catalyzing both novel perspectives new approaches research. In this review, we summarize analytical approaches, evolutionary SCDC animals. We also discuss methodological challenges discrepancies encountered research, which often underlie conflicting results. Finally, what outstanding questions opportunities exist for future research on SCDC.
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