Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis.

摘要: The adrenal glands are able to modulate immune responses through neuroimmunoendocrine interactions and cortisol secretion that could suppress exacerbated inflammation such as in inflammatory bowel disease (IBD). Therefore, here we evaluated the role of these experimental colitis induced by 3% dextran sulfate sodium (DSS) C57BL/6 mice subjected adrenalectomy, with or without glucocorticoid (GC) replacement. Mice succumbed adrenals a higher clinical score augmented systemic levels IL-6 lower LPS. Furthermore, adrenalectomy negatively modulated regulatory markers. absence resulted tolerogenic lamina propria dendritic cells but no compensatory local production corticosterone decreased mucosal associated increased IFN-γ FasL intestine. To clarify importance GC this scenario, replacement adrenalectomized restored different markers same degree observed DSS group. Finally, is first time adrenal-derived hormones, especially GC, were differential modulation gut infiltrate, also pointing relationship between These findings may elucidate some mechanisms dictate outcome.