Genetic and Environmental Effects on Offspring Alcoholism

摘要: Context Although there is now considerable evidence that genetic effects play a critical role in the development of alcohol dependence (AD), theoretical and methodological limitations this literature require caution describing etiology disorder. Objective To disentangle environmental on AD by means infrequently used, yet potentially powerful, offspring-of-twins design. Design Offspring twins. Participants Male monozygotic dizygotic twins concordant or discordant for control pairs from Vietnam Era Twin Registry were assessed, as offspring these mothers offspring. Interventions Structured psychiatric interviews. Main Outcome Measures Participants' psychiatric, abuse (AA), histories ( DSM-IV ). Results with history significantly more likely to exhibit AA than nonalcoholic fathers. an alcohol-abusing twin whose co-twin was also In contrast, unaffected (ie, no dependence) Conclusions These findings support hypothesis family do make difference accounting outcomes, particular, low-risk environment absence parental alcoholism) can moderate impact high risk regarding alcohol-use disorders.